Chrissy Metz, Serena Williams & More Weighing in on Weight Loss Drugs

Sarah Grossbart Sat, August 15, 2026 at 7:00 AM UTC

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Originally appeared on E! Online

For more than half a decade, Chrissy Metz was determined to avoid the big three.

As in Ozempic, Mounjaro, Wegovy...

Of course, the list of GLP-1 weight loss injectables and the public's ability to rattle them off has vastly expanded since news of oh-oh-oh Ozempic shot to the top of public consciousness in 2023.

By then, the This Is Us star was already pretty well-versed in the type 2 diabetes medications that can be prescribed for weight loss. And also quite averse.

"I was very skeptical of starting a GLP-1 for a very long time," the actress recently explained in an exclusive interview with E! News. "I'm just very diligent about what and how things work within the body."

But after listening to a friend's "very thorough" research, she was ready to give it a shot.

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She'd "been on diets for a very, very long time, since I was a kid," the 45-year-old explained to E!. But she'd never been able to quiet the food noise until she partnered with Ro, the telehealth company Serena Williamsteamed up with when she was determined to ace a weight loss journey of her own.

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Metz's motivation wasn't "doing it purely for vanity's sake," she explained, but rather a desire to carve out her own happily ever after.

As she embarked on a three-month Broadway run in & Juliet, the This Is Me author recalled asking herself: "'How can I be the healthiest for the longest?'" she recounted. "'How can I really make it a priority for my future and what I want my life to look like?'"

And she's not the only star to learn that parting with her previously held beliefs surrounding weight loss drugs is definitively not sweet sorrow.

Having spent her share of time crying on the kitchen floor over her postpartum wellness journey, Trisha Paytas has been thrilled with the 26 pounds she's shed using Zepbound.

"We see so many people losing weight and kind of denying being on a GLP-1," she explained to People in June, "but I just wanna be as transparent as possible so people know why and then other people who have the same issues with food can feel if it's right for them."

And they're just the latest stars to serve up their reasons for trying the medication. Check out who else has weighed in.

Chrissy Metz

After years of feeling "very skeptical of starting a GLP-1" actressChrissy Metzdecided it was time to give it a shot. "I'm just very diligent about what and how things work within the body," theThis Is Usalum explained in anexclusive August 2026 interview with E! News, "and I'm like, 'Oh, I don't know what that's gonna be like.'"But after listening to a friend's "very thorough" research, she teamed with telehealth company Ro."I've been on diets for a very, very long time, since I was a kid, and I know I can lose weight," she explained, "but I didn't know that I could quiet food noise and I didn't know there were other factors. There's so much shame around being in a bigger body, so just knowing that I wasn't doing it purely for vanity's sake."Because the result that makes her want to sing its praises is the way it helps her push through eight shows a week in Broadway's& Juliet."It's helped with inflammation," she noted. "It's helped with just overall health lab work and blood work and just generally just an overall feeling of space and creativity that the food noise has quieted. It opens up just more ability to be present."Trisha Paytas

Having gained 80 pounds in back-to-back pregnancies withMalibu Barbie,ElvisandAquaman,Trisha Paytaswas eager to dive intoa new weight loss strategy."I was starving myself, killing myself in the gym, eating grapefruit for dinner and I just was not losing it," she recounted toPeoplein June 2026. "And I've tried everything else in my life, like all the fad diets, so I was like, 'OK, I should just try a GLP-1 if it's working for so many people.'"Six weeks into her Zepbound journey, she was down 26 pounds and making plans to run 26.2 miles as she considers a 2027 marathon."I've lived 38 years of my life obsessing about food," she explained, "it would be nice to live the next 38 just thinking about food a normal amount."Serena Williams

Following years of struggle following the 2017 birth of eldest daughterAlexis,Serena Williamswas ready toserve. "No matter what I did—running, walking, I would walk for hours because they say that’s good," she detailed on Today in 2025, "I literally was playing a professional sport—and I could never go back to where I needed to be for my health."After a bit of back-and-forth volleying, the Ro partner stuck with a GLP-1 medicationthat helped her drop 31 pounds.Sharing her desire to do away withthe idea that the medication is a "shortcut,"she explained, "As an athlete and as someone that has done everything, I just couldn't get my weight to where I needed to be at a healthy place."Oprah Winfrey

More than three decades afterOprah Winfreywheeled a wagon of fat onto her talk show stage, she's put her new wellness strategy on display. When she revealed in December 2023that she was taking a weight loss medication, "I was like an anomaly," she acknowledged on a January 2025episode ofThe Oprah Podcast, "an anomaly in that I was willing to say it."And that wasn'tall that she shared."One of the things that I realized the very first time I took a GLP-1 was that all these years I thought that thin people, those people just had more willpower," she noted. "They ate better foods. They were able to stick to it longer. They never had a potato chip."But when she started her regimen, she realized "that, 'Oh, they're not even thinking about it. They're only eating when they're hungry and they're stopping when they're full.'"Meghan Trainor

The couple that pees together also pokes together. Following the 2021 birth of eldest sonRiley, singerMeghan Trainorand her actor husbandDaryl Sabaradid the 75 Hard challenge, "and, man, did we crush,” Meghandetailed during an April 2025 episodeof the couple’sWorkin’ On Itpodcast. “Then, we heard more and more of our friends—and even our doctors—were on Mounjaro and Ozempic.”They each opted to get on the lowest dose possible of Monjaro, combining the shots with exercise and balanced meals. “Daryl and I both do everything together," the "All About That Bass" singer explained. "And we started that journey.”Whitney Leavitt

Years beforeDancing With the Stars, theSecret Lives of Mormon Wivesstar revealed she was taking semaglutide injections—which are sold under brand names like Ozempic and Wegovy—to lose weight."I have a secret sauce," she said onYouTubein Janaury 2023. "It's killing the fat and I'm just peeing it out. At least, that's how I understand it."Jonathan Van Ness

TheQueer Eyestar explained in October 2025 that they started using a GLP-1 after a health scare in 2023.“I decided then that after the medical issue, I was going to get a colonoscopy,” Jonathan said in a TikTok video, “and if I didn't have anything severely wrong with me, I was going to go on a GLP-1, because I just didn't feel good.”They added, “As I've lost weight and I got into [Pilates classes at] Solidcore, my body has never looked like this,” Jonathan said. “My body's never in my whole life—I've always wanted to have an ab. I've never had abs. And I feel really good, so I'm taking my shirt off a lot.”Despite losing 70 pounds with the help of the drug, Jonathan re-emphasized their stance on body positivity."I'm all about body neutrality,” they continued. “The way that you look does not define your worth, doesn't define your lovableness. You are worth love and worth celebration no matter what your body looks like.”Rosie O'Donnell

The comedian has been on the anti-Type 2 diabetes medication Mounjaro since late 2022. In May 2025, she showcased her dramatic weight loss."I cant believe this is me now," Rosie wrote on herInstagram, "#mounjaro #weightloss #bodydismorphia."Kendra Wilkinson

FormerGirls Next DoorstarKendra Wilkinsongave one unnamed weight loss injectable a shot. Exactlyone, to be precise. “I started the weight loss shots,”she wrote on her Instagram Storiesin April 2025. “Only did one. Nevermind. Throwing away!!”However, she resumed what she called her "GLP-1 journey" in March 2026,writing on Instagramthat she was "being really intentional" about her usage this time around."For me, it wasn’t just about weight… it was about feeling better, having more energy, and actually trusting the process instead of rushing it," she continued. "I wanted something that felt transparent, supportive, and realistic for my lifestyle."Nikki Glaser

The Golden Globes host fiercly defended the use of Ozempic in March 2025, calling for people to be more open about using the medication.“I love it. I’m like, ‘Do it,’” she said onThe Tonight Show Starring Jimmy Fallon. “I have no judgment. If you want to do Ozempic, hell yeah, girl.”She added,“I want people to feel more comfortable talking about doing it, because I feel like there's this shame,” she continued. “The shame is only from thin people who want you to stay fat. That's really where it's coming from. They're so mad that you're getting thin now, because that's alltheyhave, right? You’re dynamic, you have a good personality, and they're so mad.”Brooks Nader

In December 2024, the model said she had once taken Ozempic but stopped after she started competing onDancing With the Starsthe previous fall."I took, like, a little bit when it first came out, and everyone was doing it," Nader toldUs Weekly. "It made me really nauseous. I liked it—I am not going to lie—and when I went onDancing with the Stars, I could not do both."Brooks said she "lost a little bit of the motivation and the strength to work out" by taking the medication. "It was one or the other," she said, "and I picked dancing. I put the shot away."Bonnie Chapman

Dog the Bounty Hunter's daughter shared in November 2024 that she had lost 58 pounds in 10 months thanks to a change in diet and the use of the weight loss medication Tirzepatide, adding, "I am able to look at myself in the mirror and feel so proud of where I've gotten."But before finding the solution that works for her, she had a rough go with Ozempic. "I hated it," sherevealed to E! News. "I could not eat without feeling nauseous. I could not eat at all, sometimes. My body did not like it."Jessel Taank

The Real Housewives of New York Citystarshot down speculationabout her glow-up between seasons 14 and 15.“I think that when you’re in reality TV, it’s so natural to be like, ‘Oh, she got plastic surgery or she did this or she’s on Ozempic,’” she toldUs Weeklyin October 2024. “I actually f--king hate Ozempic. I would never put needles in myself.”Lizzo

After several fans speculated on social media thatLizzoused Ozempic to lose weight, following a post she shared in which she showcased a slimmer figure, the Grammy winner posted this video, set to a viral TikTok sound bite ofChristoph Waltz's character saying, "It's like a reward" fromDjango Unchained.Later, though, the musician admitted she gave some injectibles a shot."I tried everything," Lizzo told host Trisha Paytas during a June 2025 episode of theJust Trishpodcast, before explaining why she wound up ditching GLP-1 medications early on in her journey. "Ozempic works because you eat less food, yeah? So if you eat right, it makes you feel full. But if you can just do that on your own and get mind over matter, it's the same thing."Lottie Moss

Kate Moss' little sis revealed why getting on Ozempicwas "the worst decision I ever made,"during a September 2024 episode of herDream Onpodcast.After taking a dosage meant for those roughly 220 pounds or more, the model was struggling to keep any food or water down and landed in the emergency room.“I literally had a seizure from how dehydrated I was, which honestly was the scariest thing that’s ever happened to me in my life,” she admitted. “My friend had to hold my feet down. It was so scary, the whole situation. My face was clenching up, my whole body was tense.”Jon Gosselin

TheJon & Kate Plus 8alum toldPage Sixin April 2024 that he lost 32 pounds in two months after taking injections of semaglutide, the generic form of Ozempic."You know what's annoying?" he said. "The regret of not starting it 10 years ago."Ree Drummond

ThePioneer Womanstar shared on herblogin March 2024 that her 50-pound weight loss in 2022 was not due to taking Ozempic or similar medications.She added, "But you'll never hear a second of judgment from me about people who choose that direction!"Tracy Morgan

In August 2023, the30 Rockalum said onToday With Hoda and Jennathat he lost weight on Ozempic because it supressed his appetite.In March 2024, his health journey appeared totake a surprising turn. "I've learned to out-eat Ozempic," he said onThe Tonight ShowStarring Jimmy Fallon. "I gained 40 pounds."Later that month, he clarified to E! News that he was joking, adding, "Ozempic did great by me and I was glad to use it."Caroline Stanbury

TheReal Housewives of Dubaistar opened up about using Ozempic after going through a "midlife crisis" at 45."After 40, we all know it's very, very hard to lose weight," she said in the May 22 episode of herpodcastUncut & Uncensored With Caroline Stanbury."But I met so many 40-year-old women going, 'How have you done it?' And I don't want to lie to you, I used Ozempic, which I think is one of the best tools if you're able to use it."Jennifer Aydin

The Real Housewives of New Jerseystar declared "I am not on Ozempic" during a July 2024Watch What Happens Liveinterview before hilariously adding, "I'm on Mounjaro, okay. I'm sorry! I love being this weight, I love it! I have so much energy if you couldn't tell."Kandi Burruss

The Real Housewives of Atlantaalumrevealed her failed attempt to lose weightwith the injectable medication."It didn't curb my appetite. I know some people are like, ‘Oh, I can't eat.' Not me! I was eating appetizers, a regular meal and dessert, okay? It didn't stop anything for me," she shared in June 2024. "When you see it worked for other people and it doesn't work for you, it makes you depressed. Realistically, it makes you feel like, ‘What is wrong with me? Why is it not working for me?'"Brooke Burke

“I can’t speak medically about it, but I do know that there’s so much information about what’s working and what’s not,” she shared during part of an interview withFox News Digital. “I think that Ozempic has some great benefits, and I also think it has some dangers.”Jade Thirlwall

TheLittle Mixalum, who has been open about her past struggles with anorexia, admitted that avoiding Ozempic was difficult amid online speculation about her weight“I have a daily battle with myself not to go on Ozempic,” Jade told The Guardian in August 2025. “I don’t judge people that do, but because I have a history of eating disorders, I don’t know where taking something like that would end for me.”Tori Spelling

TheBeverly Hills, 90210tried the drug to help her slim down after giving birth to her sonBeauin 2017."I tried Ozempic and it didn't work for me," she shared in an April 2024 episode of hermisSPELLINGpodcast, "so I went on Mounjaro, which did do the trick and I did lose weight."

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